Open AccessImmunomodulation by anticancer cell cycle inhibitors
Author(s) -
Giulia Petroni,
Silvia C. Formenti,
Selina ChenKiang,
Lorenzo Galluzzi
Publication year - 2020
Publication title -
nature reviews. immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 20.529
H-Index - 390
eISSN - 1474-1741
pISSN - 1474-1733
DOI - 10.1038/s41577-020-0300-y
Subject(s) - cyclin dependent kinase 6 , palbociclib , cell cycle , cyclin dependent kinase , context (archaeology) , cancer research , cancer , medicine , cyclin dependent kinase 4 , breast cancer , kinase , immunology , biology , pharmacology , metastatic breast cancer , cyclin dependent kinase 2 , microbiology and biotechnology , paleontology
Cell cycle proteins that are often dysregulated in malignant cells, such as cyclin-dependent kinase 4 (CDK4) and CDK6, have attracted considerable interest as potential targets for cancer therapy. In this context, multiple inhibitors of CDK4 and CDK6 have been developed, including three small molecules (palbociclib, abemaciclib and ribociclib) that are currently approved for the treatment of patients with breast cancer and are being extensively tested in individuals with other solid and haematological malignancies. Accumulating preclinical and clinical evidence indicates that the anticancer activity of CDK4/CDK6 inhibitors results not only from their ability to block the cell cycle in malignant cells but also from a range of immunostimulatory effects. In this Review, we discuss the ability of anticancer cell cycle inhibitors to modulate various immune functions in support of effective antitumour immunity.