Open AccessThe evolving metabolic landscape of chromatin biology and epigenetics
Author(s) -
Ziwei Dai,
Vijyendra Ramesh,
Jason W. Locasale
Publication year - 2020
Publication title -
nature reviews. genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.214
H-Index - 365
eISSN - 1471-0064
pISSN - 1471-0056
DOI - 10.1038/s41576-020-0270-8
Subject(s) - epigenome , biology , epigenetics , chromatin , histone , cellular metabolism , dna methylation , cell metabolism , epigenomics , chromatin remodeling , microbiology and biotechnology , computational biology , genetics , metabolism , dna , cell , gene expression , gene , biochemistry
Molecular inputs to chromatin via cellular metabolism are modifiers of the epigenome. These inputs - which include both nutrient availability as a result of diet and growth factor signalling - are implicated in linking the environment to the maintenance of cellular homeostasis and cell identity. Recent studies have demonstrated that these inputs are much broader than had previously been known, encompassing metabolism from a wide variety of sources, including alcohol and microbiotal metabolism. These factors modify DNA and histones and exert specific effects on cell biology, systemic physiology and pathology. In this Review, we discuss the nature of these molecular networks, highlight their role in mediating cellular responses and explore their modifiability through dietary and pharmacological interventions.