Open AccessTargeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine
Author(s) -
Anwesha Dey,
Xaralabos Varelas,
KunLiang Guan
Publication year - 2020
Publication title -
nature reviews. drug discover/nature reviews. drug discovery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 9.921
H-Index - 328
eISSN - 1474-1784
pISSN - 1474-1776
DOI - 10.1038/s41573-020-0070-z
Subject(s) - hippo signaling pathway , effector , biology , regeneration (biology) , hedgehog signaling pathway , signalling pathways , transcription factor , signal transduction , regenerative medicine , bioinformatics , cancer research , microbiology and biotechnology , gene , genetics , stem cell
The Hippo pathway is an evolutionarily conserved signalling pathway with key roles in organ development, epithelial homeostasis, tissue regeneration, wound healing and immune modulation. Many of these roles are mediated by the transcriptional effectors YAP and TAZ, which direct gene expression via control of the TEAD family of transcription factors. Dysregulated Hippo pathway and YAP/TAZ-TEAD activity is associated with various diseases, most notably cancer, making this pathway an attractive target for therapeutic intervention. This Review highlights the key findings from studies of Hippo pathway signalling across biological processes and diseases, and discusses new strategies and therapeutic implications of targeting this pathway.