Open AccessExploiting metabolic glycoengineering to advance healthcare
Author(s) -
Christian Agatemor,
Matthew J. Buettner,
Ryan Ariss,
Keerthana Muthiah,
Christopher T. Saeui,
Kevin J. Yarema
Publication year - 2019
Publication title -
nature reviews. chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 16.465
H-Index - 50
ISSN - 2397-3358
DOI - 10.1038/s41570-019-0126-y
Subject(s) - glycoconjugate , glycan , glycosylation , computational biology , biology , anticipation (artificial intelligence) , computer science , bioinformatics , biochemistry , glycoprotein , artificial intelligence
Metabolic glycoengineering (MGE) is a technique for manipulating cellular metabolism to modulate glycosylation. MGE is used to increase the levels of natural glycans and, more importantly, to install non-natural monosaccharides into glycoconjugates. In this Review, we summarize the chemistry underlying MGE that has been developed over the past three decades and highlight several recent advances that have set the stage for clinical translation. In anticipation of near-term application to human healthcare, we describe emerging efforts to deploy MGE in diverse applications, ranging from the glycoengineering of biotherapeutic proteins and the diagnosis and treatment of complex diseases such as cancer to the development of new immunotherapies.