Open AccessNADPH oxidases and oxidase crosstalk in cardiovascular diseases: novel therapeutic targets
Author(s) -
Yixuan Zhang,
Priya Murugesan,
Kai Huang,
Hua Cai
Publication year - 2019
Publication title -
nature reviews. cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.495
H-Index - 130
eISSN - 1759-5010
pISSN - 1759-5002
DOI - 10.1038/s41569-019-0260-8
Subject(s) - nadph oxidase , crosstalk , medicine , oxidative stress , reactive oxygen species , myocardial infarction , disease , pathogenesis , pharmacology , bioinformatics , cardiology , microbiology and biotechnology , biology , physics , optics
Reactive oxygen species (ROS)-dependent production of ROS underlies sustained oxidative stress, which has been implicated in the pathogenesis of cardiovascular diseases such as hypertension, aortic aneurysm, hypercholesterolaemia, atherosclerosis, diabetic vascular complications, cardiac ischaemia-reperfusion injury, myocardial infarction, heart failure and cardiac arrhythmias. Interactions between different oxidases or oxidase systems have been intensively investigated for their roles in inducing sustained oxidative stress. In this Review, we discuss the latest data on the pathobiology of each oxidase component, the complex crosstalk between different oxidase components and the consequences of this crosstalk in mediating cardiovascular disease processes, focusing on the central role of particular NADPH oxidase (NOX) isoforms that are activated in specific cardiovascular diseases. An improved understanding of these mechanisms might facilitate the development of novel therapeutic agents targeting these oxidase systems and their interactions, which could be effective in the prevention and treatment of cardiovascular disorders.