Open AccessHarmonic acoustics for dynamic and selective particle manipulation
Author(s) -
Shujie Yang,
Zhenhua Tian,
Zeyu Wang,
Joseph Rufo,
Peng Li,
D. John,
Jianping Xia,
Hunter Bachman,
PoHsun Huang,
Mengxi Wu,
Chuyi Chen,
Luke P. Lee,
Tony Jun Huang
Publication year - 2022
Publication title -
nature materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 14.344
H-Index - 483
eISSN - 1476-4660
pISSN - 1476-1122
DOI - 10.1038/s41563-022-01210-8
Subject(s) - nanotechnology , materials science , particle (ecology) , harmonic , acoustics , physics , oceanography , geology
Precise and selective manipulation of colloids and biological cells has long been motivated by applications in materials science, physics and the life sciences. Here we introduce our harmonic acoustics for a non-contact, dynamic, selective (HANDS) particle manipulation platform, which enables the reversible assembly of colloidal crystals or cells via the modulation of acoustic trapping positions with subwavelength resolution. We compose Fourier-synthesized harmonic waves to create soft acoustic lattices and colloidal crystals without using surface treatment or modifying their material properties. We have achieved active control of the lattice constant to dynamically modulate the interparticle distance in a high-throughput (>100 pairs), precise, selective and reversible manner. Furthermore, we apply this HANDS platform to quantify the intercellular adhesion forces among various cancer cell lines. Our biocompatible HANDS platform provides a highly versatile particle manipulation method that can handle soft matter and measure the interaction forces between living cells with high sensitivity.