Open AccessSupramolecular peptide constructed by molecular Lego allowing programmable self-assembly for photodynamic therapy
Author(s) -
Huangtianzhi Zhu,
Huanhuan Wang,
Bingbing Shi,
Liqing Shangguan,
Weijun Tong,
Guocan Yu,
Zhengwei Mao,
Feihe Huang
Publication year - 2019
Publication title -
nature communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.559
H-Index - 365
ISSN - 2041-1723
DOI - 10.1038/s41467-019-10385-9
Subject(s) - photodynamic therapy , supramolecular chemistry , peptide , nanotechnology , self assembly , computer science , chemistry , materials science , biochemistry , molecule , organic chemistry
Peptide self-assemblies with multiple nanostructures have great potentials in functional biomaterials, and yet the tedious and costly covalent peptide modification and the lack of facile controllability on self-assembly morphology retard the peptide-related exploration. Here we report a simple approach to fabricate a supramolecular peptide that shows programmable self-assembly with multiple morphologies and application in photodynamic therapy. Pillar[5]arene-based host−guest recognition is used to construct a supramolecular peptide, which simplify the peptide modification and promote the controllability of the self-assembly behavior. Due to the ERGDS sequences on the exterior surfaces and hydrophobic cores of self-assemblies, the nanoparticles formed from the supramolecular peptide are suitable vehicles to encapsulate a photosensitizer for photodynamic therapy. In vitro and in vivo studies demonstrate that the inherent targeting capability and supramolecular strategy greatly boost its photodynamic therapeutic efficiency. This supramolecular peptide holds promising potentials in precise cancer therapy and perspectives for the peptide modification.