Open AccessMetabolomic analysis of serum alpha-tocopherol among men in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study
Author(s) -
Wayne R. Lawrence,
Jae Yol Lim,
Jiaqi Huang,
Joshua N. Sampson,
Stephanie J. Weinstein,
Demetrius Albanês
Publication year - 2022
Publication title -
european journal of clinical nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 157
eISSN - 1476-5640
pISSN - 0954-3007
DOI - 10.1038/s41430-022-01112-7
Subject(s) - valine , metabolomics , metabolite , leucine , vitamin e , isoleucine , beta carotene , vitamin , tocopherol , medicine , alpha tocopherol , alpha (finance) , chemistry , endocrinology , biochemistry , amino acid , biology , bioinformatics , antioxidant , surgery , construct validity , patient satisfaction
The role of vitamin E in chronic disease risk remains incompletely understood, particularly in an un-supplemented state, and evidence is sparse regarding the biological actions and pathways involved in its influence on health outcomes. Identifying vitamin-E-associated metabolites through agnostic metabolomics analyses can contribute to elucidating the specific associations and disease etiology. This study aims to investigate the association between circulating metabolites and serum α-tocopherol concentration in an un-supplemented state.