Open AccessCD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles
Author(s) -
Marine Aitamer,
Hussein Akil,
Chantal Vignoles,
Maud Branchaud,
Julie Abraham,
Nathalie Gachard,
Jean Feuillard,
Marie-Odile Jauberteau,
Hamasseh Shirvani,
Danielle Troutaud,
Hafidha Bentayeb
Publication year - 2021
Publication title -
british journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.833
H-Index - 236
eISSN - 1532-1827
pISSN - 0007-0920
DOI - 10.1038/s41416-021-01611-7
Subject(s) - tropomyosin receptor kinase b , biology , cd20 , cancer research , lymphoma , neurotrophic factors , immunology , biochemistry , receptor
Small extracellular vesicles (sEVs) including exosomes, carrying the CD20, could be involved in immunotherapy resistance in diffuse large B cell lymphoma (DLBCL). We have reported endogenous brain-derived neurotrophic factor/TrkB (tropomyosin-related kinase B) survival axis in DLBCL. Here, we performed a comparative study of sEV production by germinal centre B cell (GCB) and activated B cell (ABC)-DLBCL cell lines, and analysed TrkB activation on this process.