Open AccessTIM3+ cells in gastric cancer: clinical correlates and association with immune context
Author(s) -
Ke Chen,
Yun Gu,
Yifan Cao,
Hanji Fang,
Kunpeng Lv,
Xin Liu,
Xingkang He,
Jieti Wang,
Chao Lin,
Hao Líu,
Heng Zhang,
Hongyong He,
Jiejie Xu,
He Li,
Ruochen Li
Publication year - 2021
Publication title -
british journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.833
H-Index - 236
eISSN - 1532-1827
pISSN - 0007-0920
DOI - 10.1038/s41416-021-01607-3
Subject(s) - cancer , immune system , immunotherapy , medicine , cd8 , cancer research , antibody , cancer immunotherapy , cancer cell , cytotoxic t cell , immune checkpoint , tumor infiltrating lymphocytes , t cell , immunology , biology , biochemistry , in vitro
T cell immunoglobulin and mucin domain-containing protein 3 (TIM3) is a crucial immune checkpoint and is considered as an emerging target for cancer treatment. However, the clinical significance and immune-related role of TIM3 + cells in gastric cancer remain unknown. This study aimed to investigate the clinical significance of tumour-infiltrating TIM3 + cells and their association with immune contexture in gastric cancer.