Open AccessStatin use is associated with a reduced incidence of colorectal cancer expressing SMAD4
Author(s) -
Sarah Ouahoud,
Rutger J. Jacobs,
Liudmila L. Kodach,
Philip W. Voorneveld,
Lukas J.A.C. Hawinkels,
Nikki L. Weil,
Britt van Vliet,
Ron M. C. Herings,
L. van der Burg,
Tom van Wezel,
Hans Morreau,
Marije Slingerland,
Esther Bastiaannet,
Hein Putter,
James C.H. Hardwick
Publication year - 2021
Publication title -
british journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.833
H-Index - 236
eISSN - 1532-1827
pISSN - 0007-0920
DOI - 10.1038/s41416-021-01604-6
Subject(s) - colorectal cancer , kras , statin , medicine , oncology , cancer , incidence (geometry) , physics , optics
Long-term use of statins is associated with a small reduced risk of colorectal cancer but their mechanism of action is not well understood. While they are generally believed to act on KRAS, we have previously proposed that they act via influencing the BMP pathway. The objective of this study was to look for associations between statin use and the risk of developing colorectal cancer of a particular molecular subtype.