Open AccessA risk prediction tool for individuals with a family history of breast, ovarian, or pancreatic cancer: BRCAPANCPRO
Author(s) -
Amanda L. Blackford,
Erica J. Childs,
Nancy Porter,
Gloria M. Petersen,
Kari G. Rabe,
Steven Gallinger,
Ayelet Borgida,
Sapna Syngal,
Michele L. Coté,
Ann G. Schwartz,
Michael Goggins,
Ralph H. Hruban,
Giovanni Parmigiani,
Alison P. Klein
Publication year - 2021
Publication title -
british journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.833
H-Index - 236
eISSN - 1532-1827
pISSN - 0007-0920
DOI - 10.1038/s41416-021-01580-x
Subject(s) - pancreatic cancer , ovarian cancer , breast cancer , oncology , family history , medicine , cancer , pedigree chart , gynecology , biology , genetics , gene
Identifying families with an underlying inherited cancer predisposition is a major goal of cancer prevention efforts. Mendelian risk models have been developed to better predict the risk associated with a pathogenic variant of developing breast/ovarian cancer (with BRCAPRO) and the risk of developing pancreatic cancer (PANCPRO). Given that pathogenic variants involving BRCA2 and BRCA1 predispose to all three of these cancers, we developed a joint risk model to capture shared susceptibility.