Open AccessClinical assessment of the miR-34, miR-200, ZEB1 and SNAIL EMT regulation hub underlines the differential prognostic value of EMT miRs to drive mesenchymal transition and prognosis in resected NSCLC
Author(s) -
Simon Garinet,
Audrey Didelot,
Thomas Denize,
Alexandre Perrier,
Guillaume Beinse,
Jean-Baptiste Leclère,
JeanBaptiste Oudart,
Laure Gibault,
Cécile Badoual,
Françoise Le PimpecBarthes,
Pierre LaurentPuig,
Antoine Legras,
Hélène Blons
Publication year - 2021
Publication title -
british journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.833
H-Index - 236
eISSN - 1532-1827
pISSN - 0007-0920
DOI - 10.1038/s41416-021-01568-7
Subject(s) - microrna , oncology , medicine , snail , epithelial–mesenchymal transition , lung cancer , non small cell lung cancer (nsclc) , metastasis , bioinformatics , cancer , biology , gene , ecology , biochemistry , a549 cell
Patients with non-small cell lung cancer (NSCLC) receiving curative surgery have a risk of relapse, and adjuvant treatments only translate into a 5% increase in 5-year survival. We assessed the clinical significance of epithelial-mesenchymal transition (EMT) and explored its association with the [SNAIL/miR-34]:[ZEB/miR-200] regulation hub to refine prognostic information.