Open AccessEndolysosomal ion channel MCOLN2 (Mucolipin-2) promotes prostate cancer progression via IL-1β/NF-κB pathway
Author(s) -
Hongyan Yu,
Mingxu Xie,
Zhaoyue Meng,
Chun-Yin Lo,
Franky L. Chan,
Liwen Jiang,
Xiangqi Meng,
Xiaoqiang Yao
Publication year - 2021
Publication title -
british journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.833
H-Index - 236
eISSN - 1532-1827
pISSN - 0007-0920
DOI - 10.1038/s41416-021-01537-0
Subject(s) - cancer research , prostate cancer , chemistry , ion channel , prostate , cancer , medicine , biology , endocrinology , receptor
Prostate cancer (Pca) is the most common cancer type among males worldwide. Dysregulation of Ca 2+ signaling plays important roles during Pca progression. However, there is lack of information about the role of endolysosomal Ca 2+ -permeable channels in Pca progression.