Open AccessTestosterone, sex hormone-binding globulin, insulin-like growth factor-1 and endometrial cancer risk: observational and Mendelian randomization analyses
Author(s) -
Amy Mullee,
Niki Dimou,
Naomi E. Allen,
Tracy O’Mara,
Marc J. Gunter,
Neil Murphy
Publication year - 2021
Publication title -
british journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.833
H-Index - 236
eISSN - 1532-1827
pISSN - 0007-0920
DOI - 10.1038/s41416-021-01518-3
Subject(s) - sex hormone binding globulin , mendelian randomization , endometrial cancer , hazard ratio , medicine , endocrinology , testosterone (patch) , oncology , cancer , physiology , biology , hormone , confidence interval , androgen , genetics , genotype , genetic variants , gene
Dysregulation of endocrine pathways related to steroid and growth hormones may modify endometrial cancer risk; however, prospective data on testosterone, sex hormone-binding globulin (SHBG) and insulin-like growth factor (IGF)-1 are limited. To elucidate the role of these hormones in endometrial cancer risk we conducted complementary observational and Mendelian randomization (MR) analyses.