Open AccessAssessing the role of cortisol in cancer: a wide-ranged Mendelian randomisation study
Author(s) -
Susanna C. Larsson,
WeiHsuan Lee,
Siddhartha Kar,
Stephen Burgess,
Elias Allara
Publication year - 2021
Publication title -
british journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.833
H-Index - 236
eISSN - 1532-1827
pISSN - 0007-0920
DOI - 10.1038/s41416-021-01505-8
Subject(s) - endometrial cancer , medicine , prostate cancer , odds ratio , oncology , cancer , breast cancer , genome wide association study , confidence interval , physiology , endocrinology , single nucleotide polymorphism , biology , genetics , genotype , gene
Cortisol's immunosuppressive, obesogenic, and hyperglycaemic effects suggest that it may play a role in cancer development. However, whether cortisol increases cancer risk is not known. We investigated the potential causal association between plasma cortisol and risk of overall and common site-specific cancers using Mendelian randomisation.