Open AccessTumour-associated neutrophils orchestrate intratumoural IL-8-driven immune evasion through Jagged2 activation in ovarian cancer
Author(s) -
Moran Yang,
Guodong Zhang,
Yiying Wang,
Mengdi He,
Qing Xu,
Jiaqi Lü,
Haiou Liu,
Congjian Xu
Publication year - 2020
Publication title -
british journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.833
H-Index - 236
eISSN - 1532-1827
pISSN - 0007-0920
DOI - 10.1038/s41416-020-1026-0
Subject(s) - biology , immune system , ovarian cancer , cytotoxic t cell , cancer research , tumor microenvironment , cd8 , immunology , cancer , genetics , in vitro
Tumour associated neutrophils (TANs) play a controversial role in regulating immune surveillance and immune evasion in various malignancies. Here, we investigated the relevance of TANs with the prognosis and immune microenvironment of epithelial ovarian cancer (EOC).