Open AccessBroccoli extract increases drug-mediated cytotoxicity towards cancer stem cells of head and neck squamous cell carcinoma
Author(s) -
Osama A. Elkashty,
Simon D. Tran
Publication year - 2020
Publication title -
british journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.833
H-Index - 236
eISSN - 1532-1827
pISSN - 0007-0920
DOI - 10.1038/s41416-020-1025-1
Subject(s) - cancer research , sulforaphane , head and neck squamous cell carcinoma , viability assay , sox2 , cancer stem cell , cd44 , cisplatin , stem cell , in vivo , cancer , cancer cell , cytotoxicity , cell , biology , medicine , head and neck cancer , in vitro , embryonic stem cell , chemotherapy , microbiology and biotechnology , biochemistry , gene
Head and neck squamous cell carcinomas (HNSCC) are malignant neoplasms with poor prognosis. Treatment-resistant cancer stem cell (CSC) is one reason for treatment failure. Considerable attention has been focused on sulforaphane (SF), a phytochemical from broccoli possessing anticancer properties. We investigated whether SF could enhance the chemotherapeutic effects of cisplatin (CIS) and 5-fluorouracil (5-FU) against HNSCC-CSCs, and its mechanisms of action.