Open AccessT-cell tumour exclusion and immunotherapy resistance: a role for CAF targeting
Author(s) -
Christopher J. Hanley,
Gareth J. Thomas
Publication year - 2020
Publication title -
british journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.833
H-Index - 236
eISSN - 1532-1827
pISSN - 0007-0920
DOI - 10.1038/s41416-020-1020-6
Subject(s) - immunotherapy , cancer research , cancer associated fibroblasts , cancer immunotherapy , medicine , immunology , tumor microenvironment , tumor cells , immune system
Recent studies have highlighted a major role for cancer-associated fibroblasts (CAFs) in promoting immunotherapy resistance by excluding T cells from tumours. Recently, we showed that CAFs can be effectively targeted by inhibiting the enzyme NOX4; this 'normalises' CAFs and overcomes immunotherapy resistance. Here we discuss our study and other strategies for CAF targeting.