Open AccessSuppressive myeloid cells are expanded by biliary tract cancer-derived cytokines in vitro and associate with aggressive disease
Author(s) -
Michael B. Ware,
Mohammad Y. Zaidi,
Jennifer Yang,
Michael K. Turgeon,
Alyssa M. Krasinskas,
Thomas A. Mace,
Kaitlin Keenan,
Matthew R. Farren,
Amanda N. Ruggieri,
Yiman Li,
Chao Zhang,
Zhengjia Chen,
Gregory S. Young,
Omar Elnaggar,
Zheng Che,
Shishir K. Maithel,
Tanios BekaiiSaab,
Bassel F. ElRayes,
Gregory B. Lesinski
Publication year - 2020
Publication title -
british journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.833
H-Index - 236
eISSN - 1532-1827
pISSN - 0007-0920
DOI - 10.1038/s41416-020-1018-0
Subject(s) - cytokine , peripheral blood mononuclear cell , myeloid , immune system , immunology , myeloid derived suppressor cell , cd33 , biology , cancer research , cancer , in vitro , stem cell , cd34 , suppressor , biochemistry , genetics
BTC is an aggressive disease exacerbated by inflammation and immune suppression. Expansion of immunosuppressive cells occurs in biliary tract cancer (BTC), yet the role of BTC-derived cytokines in this process is unclear.