Open AccessSuppression of G6PD induces the expression and bisecting GlcNAc-branched N-glycosylation of E-Cadherin to block epithelial-mesenchymal transition and lymphatic metastasis
Author(s) -
Yifei Wang,
Qingxiang Li,
Lixuan Niu,
Le Xu,
Yuxing Guo,
Lin Wang,
Chuanbin Guo
Publication year - 2020
Publication title -
british journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.833
H-Index - 236
eISSN - 1532-1827
pISSN - 0007-0920
DOI - 10.1038/s41416-020-1007-3
Subject(s) - cancer research , epithelial–mesenchymal transition , metastasis , cadherin , gene knockdown , cell migration , biology , chemistry , microbiology and biotechnology , cell , cancer , apoptosis , biochemistry , genetics
As the rate-limit enzyme of the pentose phosphate pathway, glucose-6-phosphate dehydrogenase (G6PD) plays important roles in tumour progression, but the exact mechanism through which G6PD controls cancer metastasis remains unclear.