Open AccessAn effective peptide vaccine strategy circumventing clonal MHC heterogeneity of murine myeloid leukaemia
Author(s) -
A-Ri Shin,
Sang-Eun Lee,
Hee-Baeg Choi,
Honglae Sohn,
Hyun-Il Cho,
TaiGyu Kim
Publication year - 2020
Publication title -
british journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.833
H-Index - 236
eISSN - 1532-1827
pISSN - 0007-0920
DOI - 10.1038/s41416-020-0955-y
Subject(s) - immunology , immunotherapy , antigen , cancer vaccine , cancer immunotherapy , vaccination , myeloid , biology , cancer research , peptide vaccine , medicine , immune system , epitope
Therapeutic cancer vaccines are an attractive approach for treating malignant tumours, and successful tumour eradication depends primarily on controlling tumour immunosuppression status as well as heterogeneity of tumour cells driven by epigenetic alterations.