Open AccessEGFR/Ras-induced CCL20 production modulates the tumour microenvironment
Author(s) -
Andreas Hippe,
Stephan Alexander Braun,
Péter Oláh,
Peter Arne Gerber,
Anne Schorr,
Stephan Seeliger,
Stephanie Holtz,
Katharina Jannasch,
Andor Pivarcsi,
Bettina Alexandra Buhren,
Holger Schrumpf,
Andreas Kislat,
Erich Bünemann,
Martin Steinhoff,
Jens W. Fischer,
Sérgio A. Lira,
Petra Boukamp,
Peter Hevezi,
Nikolas H. Stoecklein,
Thomas Hoffmann,
Frauke Alves,
Jonathan Sleeman,
Thomas Bauer,
Jörg Klufa,
Nicole Amberg,
Maria Sibilia,
Albert Zlotnik,
Anja Müller-Homey,
Bernhard Homey
Publication year - 2020
Publication title -
british journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.833
H-Index - 236
eISSN - 1532-1827
pISSN - 0007-0920
DOI - 10.1038/s41416-020-0943-2
Subject(s) - ccl20 , c c chemokine receptor type 6 , chemokine , stromal cell , cancer research , angiogenesis , chemokine receptor , biology , tumor microenvironment , metastasis , cancer , immunology , immune system , genetics , tumor cells
The activation of the EGFR/Ras-signalling pathway in tumour cells induces a distinct chemokine repertoire, which in turn modulates the tumour microenvironment.