Open AccessCD109 mediates tumorigenicity and cancer aggressiveness via regulation of EGFR and STAT3 signalling in cervical squamous cell carcinoma
Author(s) -
Xue-Tang Mo,
Thomas Leung,
Hermit Wai-Man Tang,
Michelle K.Y. Siu,
Peter Kok-Ting Wan,
Ki Chan,
Annie NgaYin Cheung,
Hextan Y. S. Ngan
Publication year - 2020
Publication title -
british journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.833
H-Index - 236
eISSN - 1532-1827
pISSN - 0007-0920
DOI - 10.1038/s41416-020-0922-7
Subject(s) - cancer research , gene silencing , carcinogenesis , biology , gene knockdown , cell growth , cell migration , cell , cancer , pathology , cell culture , medicine , gene , biochemistry , genetics
CD109 was involved in the tumorigenesis and progression of various cancers via TGF-β1 signalling and STAT3 activation. As CD109 is strongly expressed in cervical squamous cell carcinoma, this study was conducted to investigate its functional characteristics in cervical cancer.