Open AccessIntra-arterial hepatic beads loaded with irinotecan (DEBIRI) with mFOLFOX6 in unresectable liver metastases from colorectal cancer: a Phase 2 study
Author(s) -
Simon Pernot,
Olivier Pellerin,
Pascal Artru,
Carole Montérymard,
Denis Smith,
Jean-Luc Raoul,
Christelle De La Fouchardière,
Laëtitia Dahan,
Rosine Guimbaud,
David Sefrioui,
Jean-Louis Jouve,
Côme Lepage,
David Tougeron,
Julien Taı̈eb,
for Ffcd Debiri investigators
Publication year - 2020
Publication title -
british journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.833
H-Index - 236
eISSN - 1532-1827
pISSN - 0007-0920
DOI - 10.1038/s41416-020-0917-4
Subject(s) - medicine , irinotecan , colorectal cancer , response evaluation criteria in solid tumors , surgery , phases of clinical research , chemotherapy , fluorouracil , cancer , oncology , gastroenterology
Chemo-embolisation with drug-eluting beads loaded with irinotecan (DEBIRI) increased survival as compared with intravenous irinotecan in chemorefractory patients with liver-dominant metastases from colorectal cancer (LMCRC). First-line DEBIRI with systemic chemotherapy may increase survival and secondary resection.