Open AccessThe role of sex in the innate and adaptive immune environment of metastatic colorectal cancer
Author(s) -
Anita L. Ray,
Robert A. Nofchissey,
Maaz Khan,
Megan A. Reidy,
Megan R. Lerner,
Xiangyan Wu,
Shaoxuan Guo,
Spencer L Hill,
Nathaniel Weygant,
Sarah F. Adams,
Eliseo F. Castillo,
William L. Berry,
Michael B. Stout,
Katherine T. Morris
Publication year - 2020
Publication title -
british journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.833
H-Index - 236
eISSN - 1532-1827
pISSN - 0007-0920
DOI - 10.1038/s41416-020-0913-8
Subject(s) - immune system , cytokine , tumor microenvironment , chemokine , biology , colorectal cancer , immunology , cd8 , t cell , cancer research , medicine , cancer , genetics
Women with colorectal cancer (CRC) have a significant survival advantage over men. Sex influences on the tumour microenvironment (TME) are not well characterised, despite the importance of immune response in CRC. We hypothesised that sex-divergent immune responses could contribute to survival.