Open AccessEvaluation of the activity of a chemo-ablative, thermoresponsive hydrogel in a murine xenograft model of lung cancer
Author(s) -
Seóna M. Rossi,
Benedict K. Ryan,
Helena Kelly
Publication year - 2020
Publication title -
british journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.833
H-Index - 236
eISSN - 1532-1827
pISSN - 0007-0920
DOI - 10.1038/s41416-020-0904-9
Subject(s) - in vivo , pathology , ex vivo , self healing hydrogels , toxicity , medicine , cancer , lung cancer , chemistry , cancer research , biology , microbiology and biotechnology , organic chemistry
Minimally invasive intratumoural administration of thermoresponsive hydrogels, that transition from liquid to gel in response to temperature, has been proposed as a potential treatment modality for solid tumours. The aim of this study was to assess the inherent cytotoxicity of a poloxamer-based thermoresponsive hydrogel in a murine xenograft model of lung cancer.