Open AccessOmental adipocytes promote peritoneal metastasis of gastric cancer through the CXCL2–VEGFA axis
Author(s) -
Makoto Natsume,
Takaya Shimura,
Hiroyasu Iwasaki,
Yusuke Okuda,
Kazuki Hayashi,
Satoru Takahashi,
Hiromi Kataoka
Publication year - 2020
Publication title -
british journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.833
H-Index - 236
eISSN - 1532-1827
pISSN - 0007-0920
DOI - 10.1038/s41416-020-0898-3
Subject(s) - cxcl2 , angiogenesis , metastasis , cancer research , medicine , cxcl1 , pathology , cancer , biology , immunology , inflammation , chemokine , chemokine receptor
Gastric cancer (GC) patients frequently develop peritoneal metastasis; however, the underlying mechanism remains unknown. We hypothesised that omental adipocytes (OmAd) trigger GC cells towards malignant activity to induce peritoneal metastasis.