Open AccessKSHV infection skews macrophage polarisation towards M2-like/TAM and activates Ire1 α-XBP1 axis up-regulating pro-tumorigenic cytokine release and PD-L1 expression
Author(s) -
Maria Saveria Gilardini Montani,
Luca Falcinelli,
Roberta Santarelli,
Marisa Granato,
Maria Anele Romeo,
Nives Cecere,
Roberta Gonnella,
Gabriella D’Orazi,
Alberto Faggioni,
Mara Cirone
Publication year - 2020
Publication title -
british journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.833
H-Index - 236
eISSN - 1532-1827
pISSN - 0007-0920
DOI - 10.1038/s41416-020-0872-0
Subject(s) - xbp1 , cytokine , cancer research , macrophage , downregulation and upregulation , microbiology and biotechnology , biology , immunology , medicine , gene , genetics , rna , rna splicing , in vitro
Kaposi's Sarcoma Herpesvirus (KSHV) is a gammaherpesvirus strongly linked to human cancer. The virus is also able to induce immune suppression, effect that contributes to onset/progression of the viral-associated malignancies. As KSHV may infect macrophages and these cells abundantly infiltrate Kaposi's sarcoma lesions, in this study we investigated whether KSHV-infection could affect macrophage polarisation to promote tumorigenesis.