Open AccessPotential through simplicity: thymidine kinase-1 as a biomarker for CDK4/6 inhibitors
Author(s) -
Amelia McCartney,
Luca Malorni
Publication year - 2020
Publication title -
british journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.833
H-Index - 236
eISSN - 1532-1827
pISSN - 0007-0920
DOI - 10.1038/s41416-020-0858-y
Subject(s) - biomarker , thymidine kinase , breast cancer , cancer research , cyclin dependent kinase 4 , kinase , thymidine , oncology , medicine , biology , cancer , immunology , cell cycle , cyclin dependent kinase 2 , microbiology and biotechnology , biochemistry , in vitro , virus , herpes simplex virus
We describe a potential role for thymidine kinase-1, a general marker of cellular proliferation, to act as a prognostic biomarker in patients receiving CDK4/6 inhibitors for advanced hormone receptor-positive, HER2-negative breast cancer, with early data suggesting that it may also provide early indication of treatment response.