Open AccessStearoyl-CoA-desaturase-1 regulates gastric cancer stem-like properties and promotes tumour metastasis via Hippo/YAP pathway
Author(s) -
Yunhe Gao,
Jiyang Li,
Hu Xi,
Jianxin Cui,
Kecheng Zhang,
Jiabing Zhang,
Yanmei Zhang,
Wei Xu,
Wenquan Liang,
Ziwei Zhuang,
Pengpeng Wang,
Zhi Qiao,
Bo Wei,
Lin Chen
Publication year - 2020
Publication title -
british journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.833
H-Index - 236
eISSN - 1532-1827
pISSN - 0007-0920
DOI - 10.1038/s41416-020-0827-5
Subject(s) - hippo signaling pathway , gene knockdown , cancer research , downregulation and upregulation , metastasis , cancer , epithelial–mesenchymal transition , flow cytometry , stem cell , chemistry , small interfering rna , cancer stem cell , biology , microbiology and biotechnology , apoptosis , cell culture , signal transduction , immunology , transfection , biochemistry , genetics , gene
Stearoyl-CoA desaturase-1 (SCD1) is reported to play essential roles in cancer stemness among several cancers. Our previous research revealed significant overexpression of SCD1 in primary gastric cancer stem cells (GCSCs), with its functional role still unknown.