Open AccessRegulation of the small GTPase Ran by miR-802 modulates proliferation and metastasis in colorectal cancer cells
Author(s) -
Xin Wang,
Danxiu Li,
Lina Sun,
Gao-Fei Shen,
Hao Liu,
Hao Guo,
Minghui Ge,
Junrong Liang,
Ping Chen,
Jingyu Zhou,
Tianyu Cao,
Qi Wang,
Xiaoliang Gao,
Mingfu Tong,
Songhua Hu,
Yongzhan Nie,
Daiming Fan,
Xiaodi Zhao,
Yuanyuan Lu
Publication year - 2020
Publication title -
british journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.833
H-Index - 236
eISSN - 1532-1827
pISSN - 0007-0920
DOI - 10.1038/s41416-020-0809-7
Subject(s) - ran , gene silencing , cancer research , metastasis , colorectal cancer , downregulation and upregulation , biology , cancer , cell growth , protein kinase b , microrna , pi3k/akt/mtor pathway , signal transduction , microbiology and biotechnology , gene , genetics
The small GTPase Ran is upregulated in multiple cancers and fundamental for cancer cell survival and progression, but its significance and molecular mechanisms in colorectal cancer (CRC) remain elusive.