Open AccessSerine-dependent redox homeostasis regulates glioblastoma cell survival
Author(s) -
Anna L Engel,
Nadja I. Lorenz,
Kevin Klann,
Christian Münch,
Cornelia Depner,
Joachim P. Steinbach,
Michael Ronellenfitsch,
AnnaLuisa Luger
Publication year - 2020
Publication title -
british journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.833
H-Index - 236
eISSN - 1532-1827
pISSN - 0007-0920
DOI - 10.1038/s41416-020-0794-x
Subject(s) - serine hydroxymethyltransferase , serine , biology , programmed cell death , cell growth , cell culture , microbiology and biotechnology , endogeny , homeostasis , cancer research , biochemistry , apoptosis , phosphorylation , genetics
The amino acid serine is an important substrate for biosynthesis and redox homeostasis. We investigated whether glioblastoma (GBM) cells are dependent on serine for survival under conditions of the tumour microenvironment.