Open AccessNicotine exposure potentiates lung tumorigenesis by perturbing cellular surveillance
Author(s) -
Qiang Zhang,
S. Ganapathy,
Hava Avraham,
Takashi Nishioka,
Changyan Chen
Publication year - 2020
Publication title -
british journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.833
H-Index - 236
eISSN - 1532-1827
pISSN - 0007-0920
DOI - 10.1038/s41416-020-0730-0
Subject(s) - nicotine , carcinogen , lung , carcinogenesis , downregulation and upregulation , reactive oxygen species , sodium arsenite , oxidative stress , pharmacology , medicine , cancer research , physiology , biology , chemistry , microbiology and biotechnology , cancer , biochemistry , arsenic , organic chemistry , gene
Nicotine is a major tobacco component and found at circulating concentrations in smokers' bloodstreams. Although considered a non-carcinogenic substance, nicotine rapidly defuses to tissues after being inhaled, inviting effects on cellular physiology, particularly in the lung. Widespread increased use of nicotine-based e-cigarettes, especially in younger adults, creates an urgent need for improved understanding of nicotine's potential to impact human health.