Open AccessArtificial selection for host resistance to tumour growth and subsequent cancer cell adaptations: an evolutionary arms race
Author(s) -
Arig IbrahimHashim,
Kimberly A. Luddy,
Dominique Abrahams,
Pedro M. EnriquezNavas,
Sultan Damgaci,
Jiqiang Yao,
Tingan Chen,
Marilyn M. Bui,
Robert J. Gillies,
Cliona O’Farrelly,
Christina L. Richards,
Joel S. Brown,
Robert A. Gatenby
Publication year - 2020
Publication title -
british journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.833
H-Index - 236
eISSN - 1532-1827
pISSN - 0007-0920
DOI - 10.1038/s41416-020-01110-1
Subject(s) - biology , population , cancer , phenotype , cancer cell , immune system , transcriptome , immunology , cancer research , gene , genetics , gene expression , medicine , environmental health
Cancer progression is governed by evolutionary dynamics in both the tumour population and its host. Since cancers die with the host, each new population of cancer cells must reinvent strategies to overcome the host's heritable defences. In contrast, host species evolve defence strategies over generations if tumour development limits procreation.