Open AccessClinically and biologically relevant subgroups of Wilms tumour defined by genomic and epigenomic analyses
Author(s) -
Jack Brzezinski,
Sanaa Choufani,
Rodrigo Romao,
Cheryl Shuman,
Haiying Chen,
Joanna Cunanan,
Darius Bägli,
Ronald Grant,
Armando J. Lorenzo,
Rosanna Weksberg
Publication year - 2020
Publication title -
british journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.833
H-Index - 236
eISSN - 1532-1827
pISSN - 0007-0920
DOI - 10.1038/s41416-020-01102-1
Subject(s) - dna methylation , epigenomics , exome , epigenetics , biology , methylation , subgroup analysis , oncology , wilms' tumor , genome instability , bioinformatics , medicine , exome sequencing , genetics , dna , mutation , gene , confidence interval , gene expression , dna damage
Although cure rates for Wilms tumours (WT) are high, many patients receive therapy with attendant long-term complications. Our goal was to stratify WT using genome-wide analyses to identify candidate molecular features for patients who would benefit from a reduction in therapy.