Open AccessSuppression of pancreatic cancer liver metastasis by secretion-deficient ITIH5
Author(s) -
Eric D. Young,
Sharon Manley,
Thomas C. Beadnell,
Alexander E. Shearin,
Ken Sasaki,
R N Kathy Zimmerman,
Evan Kauffman,
Carolyn J. Vivian,
Aishwarya Parasuram,
Tomoo Iwakuma,
Paul M. Grandgenett,
Michael A. Hollingsworth,
Maura O’Neil,
Danny R. Welch
Publication year - 2020
Publication title -
british journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.833
H-Index - 236
eISSN - 1532-1827
pISSN - 0007-0920
DOI - 10.1038/s41416-020-01093-z
Subject(s) - metastasis , cancer research , tissue microarray , secretion , pancreas , pancreatic cancer , motility , biology , cancer , medicine , microbiology and biotechnology
Previously, we identified ITIH5 as a suppressor of pancreatic ductal adenocarcinoma (PDAC) metastasis in experimental models. Expression of ITIH5 correlated with decreased cell motility, invasion and metastasis without significant inhibition of primary tumour growth. Here, we tested whether secretion of ITIH5 is required to suppress liver metastasis and sought to understand the role of ITIH5 in human PDAC.