Open AccessThe nucleolar-related protein Dyskerin pseudouridine synthase 1 (DKC1) predicts poor prognosis in breast cancer
Author(s) -
Khloud A. Elsharawy,
Omar J. Mohammed,
Mohammed A. Aleskandarany,
Ayman Hyder,
Hekmat El-Gammal,
Mohamed Abou-Dobara,
Andrew Green,
Leslie W. Dalton,
Emad A. Rakha
Publication year - 2020
Publication title -
british journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.833
H-Index - 236
eISSN - 1532-1827
pISSN - 0007-0920
DOI - 10.1038/s41416-020-01045-7
Subject(s) - biology , nottingham prognostic index , nucleolus , breast cancer , immunohistochemistry , oncology , cohort , cancer research , nucleophosmin , cancer , medicine , genetics , immunology , myeloid leukemia , cytoplasm
Hypertrophy of the nucleolus is a distinctive cytological feature of malignant cells and corresponds to aggressive behaviour. This study aimed to identify the key gene associated with nucleolar prominence (NP) in breast cancer (BC) and determine its prognostic significance.