Open AccessDifferential association of CD68+ and CD163+ macrophages with macrophage enzymes, whole tumour gene expression and overall survival in advanced melanoma
Author(s) -
Liam Friel Tremble,
Mark McCabe,
Sidney P. Walker,
S. McCarthy,
Réiltín F Tynan,
Suzanne M. Beecher,
Réiltín Werner,
A. James P. Clover,
X Derek G Power,
Patrick F. Forde,
Cynthia Heffron
Publication year - 2020
Publication title -
british journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.833
H-Index - 236
eISSN - 1532-1827
pISSN - 0007-0920
DOI - 10.1038/s41416-020-01037-7
Subject(s) - cd163 , cd68 , arginase , biology , pathology , immunohistochemistry , melanoma , macrophage , gene expression , cancer research , phenotype , nitric oxide synthase , immunology , gene , medicine , in vitro , nitric oxide , amino acid , arginine , endocrinology , biochemistry
The density and phenotype of tumour-associated macrophages have been linked with prognosis in a range of solid tumours. While there is strong preclinical evidence that tumour-associated macrophages promote aspects of tumour progression, it can be challenging to infer clinical activity from surface markers and ex vivo behaviour. We investigated the association of macrophage infiltration with prognosis and functional changes in the tumour microenvironment in primary human melanoma.