Open AccessPre-clinical animal models are poor predictors of human toxicities in phase 1 oncology clinical trials
Author(s) -
Johnique T. Atkins,
Goldy C. George,
Kenneth R. Hess,
Kathrina L. Marcelo-Lewis,
Ying Yuan,
Gautam Borthakur,
Sean Khozin,
Patricia LoRusso,
David S. Hong
Publication year - 2020
Publication title -
british journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.833
H-Index - 236
eISSN - 1532-1827
pISSN - 0007-0920
DOI - 10.1038/s41416-020-01033-x
Subject(s) - medicine , clinical trial , toxicity , common terminology criteria for adverse events , oncology , adverse effect , phases of clinical research , predictive value , kappa , linguistics , philosophy
Our objective was to determine the correlation between preclinical toxicity found in animal models (mouse, rat, dog and monkey) and clinical toxicity reported in patients participating in Phase 1 oncology clinical trials.