Open AccessDevelopment of a protein-based system for transient epigenetic repression of immune checkpoint molecule and enhancement of antitumour activity of natural killer cells
Author(s) -
Yoichi Teratake,
Tomoki Takashina,
Kenta Iijima,
Tetsushi Sakuma,
Takashi Yamamoto,
Yukihito Ishizaka
Publication year - 2020
Publication title -
british journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.833
H-Index - 236
eISSN - 1532-1827
pISSN - 0007-0920
DOI - 10.1038/s41416-019-0708-y
Subject(s) - dna methylation , immune system , cancer research , biology , epigenetics , effector , immune checkpoint , natural killer cell , endogeny , cancer cell , microbiology and biotechnology , immunotherapy , chemistry , immunology , gene expression , cytotoxic t cell , gene , cancer , in vitro , biochemistry , genetics
Immune checkpoint blockade (ICB) therapy improved the prognosis of cancer patients, but general administration of ICBs occasionally induces side effects that include immune-related adverse events and tumour hyper-progression. Here, we established a protein-based system, by which endogenous expression of IC molecule in natural killer (NK) cells was transiently repressed on enhancement of their antitumour activity.