Open AccessHigh endothelial venules are associated with microsatellite instability, hereditary background and immune evasion in colorectal cancer
Author(s) -
Pauline L. Pfuderer,
Alexej Ballhausen,
Florian Seidler,
Hans Jürgen Stark,
Niels Grabe,
Ian Martin Frayling,
Ann Ager,
Magnus von Knebel Doeberitz,
Matthias Kloor,
Aysel Ahadova
Publication year - 2019
Publication title -
british journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.833
H-Index - 236
eISSN - 1532-1827
pISSN - 0007-0920
DOI - 10.1038/s41416-019-0514-6
Subject(s) - microsatellite instability , biology , immune system , dna mismatch repair , lymphocyte , colorectal cancer , lynch syndrome , pathology , immunology , cancer , medicine , microsatellite , genetics , gene , allele
Microsatellite-unstable (MSI) tumours show a high load of mutational neoantigens, as a consequence of DNA mismatch repair deficiency. Consequently, MSI tumours commonly present with dense immune infiltration and develop immune evasion mechanisms. Whether improved lymphocyte recruitment contributes to the pronounced immune infiltration in MSI tumours is unknown. We analysed the density of high endothelial venules (HEV) and postcapillary blood vessels specialised for lymphocyte trafficking, in MSI colorectal cancers (CRC).