Open AccessCombined kidney and hematopoeitic cell transplantation to induce mixed chimerism and tolerance
Author(s) -
Robert Lowsky,
Samuel Strober
Publication year - 2019
Publication title -
bone marrow transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 127
eISSN - 1476-5365
pISSN - 0268-3369
DOI - 10.1038/s41409-019-0603-4
Subject(s) - medicine , transplantation chimera , immune tolerance , transplantation , immunology , hematopoietic cell , kidney transplantation , human leukocyte antigen , haematopoiesis , immunosuppression , immune system , stem cell , biology , antigen , genetics
Based on preclinical studies, combined kidney and hematopoietic cell transplantation was performed on fully HLA matched and haplotype matched patients at the Stanford University Medical Center. The object of the studies was to induce mixed chimerism, immune tolerance, and complete immunosuppressive drug withdrawal. Tolerance, persistent mixed chimerism, and complete withdrawal was achieved in the majority of fully matched patients. Persistent mixed chimerism and partial withdrawal has been achieved in the haplotype matched patients at present.