z-logo
open-access-imgOpen Access
Deciphering the chronology of copy number alterations in Multiple Myeloma
Author(s) -
Anıl Aktaş Samur,
Stéphane Minvielle,
Masood A. Shammas,
Mariateresa Fulciniti,
Florence Magrangeas,
Paul G. Richardson,
Philippe Moreau,
Michel Attal,
Kenneth C. Anderson,
Giovanni Parmigiani,
Hervé AvetLoiseau,
Nikhil C. Munshi,
Mehmet K. Samur
Publication year - 2019
Publication title -
blood cancer journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.607
H-Index - 51
ISSN - 2044-5385
DOI - 10.1038/s41408-019-0199-3
Subject(s) - biology , multiple myeloma , somatic evolution in cancer , copy number variation , chromosomal translocation , copy number analysis , genetics , gene duplication , cancer research , genome , gene , computational biology , immunology
Multiple myeloma (MM) and its precursor condition MGUS are characterized by chromosomal aberrations. Here, we comprehensively characterize the order of occurrence of these complex genomic events underlying MM development using 500 MGUS, and MM samples. We identify hyperdiploid MM (HMM) and non-HMM as genomically distinct entities with different evolution of the copy number alterations. In HMM, gains of 9,15 or 19 are the first and clonal events observed as clonal even at MGUS stage. These events are thus early and may underlie initial transformation of normal plasma cells to MGUS cells. However, CNAs may not be adequate for progression to MM except in 15% of the patients in whom the complex subclonal deletion events are observed in MM but not MGUS. In NHMM, besides the driver translocations, clonal deletion of 13 and 1q gain are early events also observed in MGUS. We combined this information to propose a timeline for copy number alteration.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.
Having issues? You can contact us here