Open AccessDifferential placental CpG methylation is associated with chronic lung disease of prematurity
Author(s) -
Wesley M. Jackson,
Hudson P. Santos,
Hadley J. Hartwell,
W. Adam Gower,
Divya Chhabra,
James S. Hagood,
Matthew M. Laughon,
Alexis Payton,
Lisa Smeester,
Kyle Roell,
T. Michael O’Shea,
Rebecca C. Fry
Publication year - 2021
Publication title -
pediatric research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.056
H-Index - 150
eISSN - 1530-0447
pISSN - 0031-3998
DOI - 10.1038/s41390-021-01868-x
Subject(s) - dna methylation , methylation , cpg site , epigenetics , fetus , biology , placenta , genetics , pregnancy , gene , gene expression
Chronic lung disease (CLD) is the most common pulmonary morbidity in extremely preterm infants. It is unclear to what extent prenatal exposures influence the risk of CLD. Epigenetic variation in placenta DNA methylation may be associated with differential risk of CLD, and these associations may be dependent upon sex.