Open AccessButyrate supplementation to pregnant mice elicits cytoprotection against colonic injury in the offspring
Author(s) -
Maria E. Barbian,
Joshua Owens,
Crystal Naudin,
Patricia W. Denning,
Ravi Patel,
Rheinallt Jones
Publication year - 2021
Publication title -
pediatric research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.056
H-Index - 150
eISSN - 1530-0447
pISSN - 0031-3998
DOI - 10.1038/s41390-021-01767-1
Subject(s) - cytoprotection , offspring , butyrate , medicine , physiology , pregnancy , andrology , biology , biochemistry , genetics , oxidative stress , fermentation
Maternal diet during pregnancy can impact progeny health and disease by influencing the offspring's gut microbiome and immune development. Gut microbial metabolism generates butyrate, a short-chain fatty acid that benefits intestinal health. Here we assess the effects of antenatal butyrate on the offspring's gastrointestinal health. We hypothesized that antenatal butyrate supplementation will induce protection against colitis in the offspring.