Open AccessAzithromycin reduces inflammation-amplified hypoxic–ischemic brain injury in neonatal rats
Author(s) -
John Barks,
Yiqing Liu,
Ian A Dopp,
Faye S. Silverstein
Publication year - 2021
Publication title -
pediatric research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.056
H-Index - 150
eISSN - 1530-0447
pISSN - 0031-3998
DOI - 10.1038/s41390-021-01747-5
Subject(s) - neuroprotection , medicine , inflammation , brain damage , anesthesia , hypoxia (environmental) , forelimb , neuroinflammation , chemistry , organic chemistry , oxygen , anatomy
Systemic inflammation amplifies neonatal hypoxic-ischemic (HI) brain injury. Azithromycin (AZ), an antibiotic with anti-inflammatory properties, improves sensorimotor function and reduces tissue damage after neonatal rat HI brain injury. The objective of this study was to determine if AZ is neuroprotective in two neonatal rat models of inflammation-amplified HI brain injury.