Open AccessCPAP-induced airway hyper-reactivity in mice is modulated by hyaluronan synthase-3
Author(s) -
Catherine Mayer,
Abhrajit Ganguly,
Aubrey Mayer,
Christina M. Pabelick,
Y. S. Prakash,
Vince C Hascall,
Ron J Midura,
Valbona Cali,
Chris A. Flask,
Bernadette O. Erokwu,
Richard J. Martin,
Peter M. MacFarlane
Publication year - 2021
Publication title -
pediatric research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.056
H-Index - 150
eISSN - 1530-0447
pISSN - 0031-3998
DOI - 10.1038/s41390-021-01695-0
Subject(s) - continuous positive airway pressure , hyaluronan synthase , context (archaeology) , airway , medicine , lung , hyaluronic acid , endocrinology , anesthesia , biology , anatomy , paleontology , obstructive sleep apnea
Continuous positive airway pressure (CPAP) is a primary mode of respiratory support for preterm infants. Animal studies have shown long-term detrimental effects on lung/airway development, particularly airway (AW) hyper-reactivity, as an unfortunate consequence of neonatal CPAP. Since the hyaluronan (HA) synthesizing enzyme hyaluronan synthase-3 (HAS3) is involved in various adult pulmonary disorders, the present study used a neonatal mouse model to investigate the role of HAS3 in CPAP-induced AW hyper-reactivity.