Open AccessSalivary microbiome differences in prepubertal children with and without adrenal androgen excess
Author(s) -
Brittany K. Wise-Oringer,
Anne Claire Burghard,
Heekuk Park,
Richard J. Auchus,
Sharon E. Oberfield,
AnneCatrin Uhlemann
Publication year - 2021
Publication title -
pediatric research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.056
H-Index - 150
eISSN - 1530-0447
pISSN - 0031-3998
DOI - 10.1038/s41390-021-01661-w
Subject(s) - adrenarche , microbiome , medicine , endocrinology , congenital adrenal hyperplasia , androgen , androgen excess , prevotella , insulin resistance , overweight , veillonella , biology , physiology , obesity , streptococcus , bioinformatics , polycystic ovary , hormone , genetics , bacteria
Premature adrenarche is a condition of childhood adrenal androgen excess (AAE) in the absence of gonadotropin-dependent puberty, and has been linked to insulin resistance and progression to metabolic syndrome. Microbial dysbiosis is associated with progression of inflammatory states and chronic diseases. Here, we aimed to examine the salivary microbiomes of children with AAE and assess the relationship with adrenal androgens and metabolic parameters.