Open AccessAssociations between neurofilament light-chain protein, brain structure, and chronic kidney disease
Author(s) -
Ellen van der Plas,
Olivia Lullmann,
Lauren Hopkins,
Jordan L. Schultz,
Peg Nopoulos,
Lyndsay A. Harshman
Publication year - 2021
Publication title -
pediatric research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.056
H-Index - 150
eISSN - 1530-0447
pISSN - 0031-3998
DOI - 10.1038/s41390-021-01649-6
Subject(s) - kidney disease , renal function , medicine , confidence interval , kidney , magnetic resonance imaging , endocrinology , pathology , urology , radiology
Neurofilament light-chain (NfL) protein is a blood-based marker of neuroaxonal injury. We sought to (1) compare plasma NfL levels in children with chronic kidney disease (CKD) and healthy peers, (2) characterize the relationship between NfL level and kidney function, and (3) evaluate NfL as a predictor of abnormal brain structure in CKD.